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Distinct nitrogen isotopic compositions of healthy and cancerous tissue
In this study, we analyzed micro-biopsies of murine tumors and adjacent tissues for 15N/14N. In the tissue material derived from mice, the brain tumors had distinctly lower 15N/14N than healthy neural tissue. With this work, we propose a new approach for micro-biopsy-based diagnosis of malignant cancer and open a new avenue to investigate cancer metabolism.
Nitrogen isotopic composition as a gauge of tumor cell anabolism-to-catabolism ratio
Our study found consistent links between lower nitrogen isotope ratios and higher tumor cell density in breast, lung, and kidney cancers. Aggressive cancers show more pronounced 15N depletion, hinting at a more efficient nitrogen usage for growth. We suggest analyzing nitrogen isotopes could aid in biopsy screening and understanding tumor nitrogen metabolism.